IHC displayed that the expression of Ki-67, MMP2, N-cadherin and PCNA were meaningfully decreased in CRS + LV-ALDH3A1 group, while the expression of ALDH3A1 and E-cadherin in CRS + LV-ALDH3A1 group was higher than that in CRS + NC Group (Fig. 5f). This evidence concerns the gene MMP2 and congenital rubella syndrome.