RPN1 and renal carcinoma: Knockdown of RPN1 conferred increased resistance of UMRC6 renal cancer cells to disulfidptosis, whereas NCKAP1 slowed down the formation of disulfide bonds induced by glucose starvation and facilitated the detachment of f-actin contraction and depolymerization from the cell membrane in UMRC6 cells, thus providing some degree of protection to the cellular cytoskeleton.