Genetic manipulation of CPA factors has been shown to alter APA patterns, dysregulate gene and protein expression, and drive cancer phenotypes (Masamha et al. 2014; Zhang et al. 2017; Brumbaugh et al. 2018; Chen et al. 2018; Park et al. 2018; Tan et al. 2018; Zhang and Zhang 2018; Chu et al. 2019; Xiong et al. 2019; Fang et al. 2020; Li et al. 2020, 2021). Here, CPA1 is linked to cancer.