NFKB1 and colorectal carcinoma: In addition, an involvement of β1-integrin surface receptors with known link to inflammation-modulator NF-κB as well as neoangiogenesis-inducer HIF-1α was demonstrated in CRC cells (HCT-116, RKO, SW480) (Table 2) and an interruption of these connections led to apoptosis [39], [41].