TP53 and colorectal carcinoma: The repression of NF-κB as well as its supplying triggers (cytokines, enzymes, growth factors) in CRC cells was demonstrated in various cell lines, such as HCT-116, SW480 and RKO [39], [84], [113], and is directly associated with p53-related down-regulation of cell plasticity and apoptosis induction (Table 2), because it results in insulin-like growth factor (IGF) receptor blockade leading to apoptosis [113].