TP53 and colorectal carcinoma: In addition, there is an inverse regulation between p53 and the major inflammatory transcription factor, nuclear factor kappa-B (NF-κB), i.e., phosphorylated pro-inflammatory NF-κB inhibits pro-apoptotic activation of p53 [14] and an induced p53-related apoptosis suppresses the activation of NF-κB [15] in CRC cells.