TP53 and colorectal carcinoma: This becomes tangible in different CRC cell lines, HCT-116 and RKO for example, through an inhibition of migratory markers such as matrix metalloproteinase (MMP)-9 as well as CXC motif chemokine receptor (CXCR)4 and at the same time an up-regulation of p53 and caspase-3 activation is thereby made possible [65], necessary for plasticity-containment and apoptosis-initiation [75].