In addition, by down-regulation of NF-κB including its end products such as MMP-9, and up-regulation of p53 and intercellular junctions in parallel, resveratrol inhibits not only EMT but also enhances CRC cells‘ sensitivity to the standard chemotherapeutic drug 5-FU [84] (Table 1). This evidence concerns the gene NFKB1 and colorectal carcinoma.