Furthermore, the activation of pro-apoptotic genes such as PUMA, phorbol-12-myristate-13-acetate-induced protein 1 (Noxa), Bax, and BH3 interacting domain death agonist (Bid) are of great importance in cancer cells including CRC [11], [13] (Fig. 3). Here, PMAIP1 is linked to colorectal carcinoma.