NFKB1 and colorectal carcinoma: Furthermore, against the background of a known crosstalk between Hippo/YAP and NF-κB cascades, it is also understandable that resveratrol uses an activation of protein kinase Hippo and its downstream effector YAP to initiate apoptosis and inhibit cell phenotypic plasticity (Table 2) in CRC cells [117].