Of great interest is particularly the finding that the activation of p38, for instance in SW480 or SW620 cells, entails the initiation of PUMA (p53 upregulated modulator of apoptosis)/p53 signaling pathway [99] (Fig. 3), so that this signaling can be viewed as part or prelude to this main apoptosis cascade as well as an interesting molecular target to suppress CRC progression. The gene discussed is BBC3; the disease is colorectal carcinoma.