TP53 and colorectal carcinoma: Of great interest is particularly the finding that the activation of p38, for instance in SW480 or SW620 cells, entails the initiation of PUMA (p53 upregulated modulator of apoptosis)/p53 signaling pathway [99] (Fig. 3), so that this signaling can be viewed as part or prelude to this main apoptosis cascade as well as an interesting molecular target to suppress CRC progression.