TP53 and colorectal carcinoma: Considering its pro-apoptotic properties (Table 2), a resveratrol treatment directly activates the cascades of caspase-3/-6/-8/-9 [84], [101], [102], [103] and thus apoptosis in CRC cells via up-regulation of ROS [104], nitric oxide (NO), p53 signaling [102], modulation of Bax/Bcl-2 homologous antagonist/killer (Bak) ratio [102], [105], [106] or p38/MAPK pathway [107], [108], [109], [110].