TP53 and colorectal carcinoma: While the authors of earlier studies (mainly up to 2008) attributed resveratrol’s pro-apoptotic effect to a p53-independent induction of caspase cascades, numerous more recent studies (mainly from 2009 onwards) do establish a resveratrol/p53 action link and demonstrate this in different CRC cell lines and detection methods using different resveratrol concentrations as summarized in Table 3.