So far, there is not a well-known biologicalrole of the NTD for the entry of the viral RNA inside the cell, whilethe RBD is known to bind the principal SARS-CoV-2 receptor ACE2, whichleads to virion internalization.52 ForMERS-CoV, the binding pocket of SA is known to be an anchor for itsspike to bind the cell membrane as a first step in the infection mechanism.12 Here, we show that the NTD plays a similarlycritical role in the infection mechanism for SARS-CoV-2. This evidence concerns the gene ACE2 and infection.