HTR6 and Alzheimer disease: The introduction of selenium into our 1,3,5-triazine-basedserotonin-receptor ligands and subsequent optimization toward selective5-HT6R resulted not only in modulating a single target(i.e., 5-HT6R) but also in mimicking GPx, which can behighly useful in AD treatment.75,76 This combination approachprovides a very promising strategy, not reported before, meeting thepolypharmacology criteria, which seem necessary to deal with neurodegenerativediseases involving several pathophysiological processes.123