HMOX1 and Alzheimer disease: Specifically, it induces the expression of hemeoxygenase-1 (HO-1), quinone oxidoreductase-1 (NQO-1), and superoxidedismutase (SOD),25,26 but it also reduces the activityand expression of beta-site amyloid precursor protein cleaving enzyme1 (BACE1), increasing the production of amyloid-β (Aβ).27 Thus, NRF2 can be considered as a promisingtarget to be activated to mitigate AD progression.