RP mutations to other rod-specific genes also result in Rho mislocalization [16–19], and mouse models for syndromic retinal ciliopathies and Leber congenital amaurosis (LCA) are caused by mutations in cilia-related genes that lead to rod degeneration in the retina due to defective ciliary ultrastructure that is comorbid with Rho mislocalization [20–24]. This evidence concerns the gene RHO and Leber congenital amaurosis.