Focusing on areas with high WT1+ and LANA+ cells within KS nodules, there were notably lower percentages of CD8+T cells and CD4+T cells in these regions (LANA = 60% vs. CD8 = 16%, p<0.001; LANA = 60% vs. CD4 = 17%, p = 0.0002; WT1 = 91% vs. CD8 = 16%, p<0.0001; and WT1 = 91% vs. CD4 = 17%, p<0.0001), whereas in areas of low WT1+/LANA+ cells immediately adjacent to nodules in the peripheral stroma, there was a higher percentage of CD8+T cells (CD8 = 67% vs LANA = 4%; p<0.01 and CD8 = 67% vs WT1 = 13.11%, p<0.0001) (Figs 6E and S3A). The gene discussed is CD4; the disease is Kaposi's sarcoma.