Indeed, some studies on NVC in adult SjD have been performed, reporting some alterations like reduced capillary density, dilated and giant capillaries, more frequently if RP was present [27–29], or even NVC scleroderma-pattern (“early” or “active”) in one-third of cases, although the NVC pattern does not apparently differ between those with positive and negative anti-SSa/Ro or anti-SSb/La antibodies or positive and negative salivary gland biopsy [30]. This evidence concerns the gene CALR and scleroderma.