CD274 and neoplasm: If M2-TAMs can be recognized as predictive markers for PD-L1 expression, strategies can be designed to target M2-TAMs either to repolarize them to a more anti-tumorigenic M1 phenotype or to reduce their recruitment to the tumor microenvironment This, in combination with PD-L1 inhibitors, could potentially remodel the immunosuppressive tumor microenvironment of PCa and convert it from “cold” to “hot,” enhancing its susceptibility to immunotherapies.