We further analyzed the signal intensity of CD68 and CD163 proteins in cancerous and normal tissues, revealing that the positive rate of CD68 in PCa was significantly higher than that in tumor-adjacent and normal tissues, with average percentages of 68.68 ± 14.72, 29.90 ± 13.15, and 13.33 ± 2.89, respectively (Figure 1B, 1C, P < 0.01). Here, CD68 is linked to posterior cortical atrophy.