For instance, both hypermethylation and down-regulation of TMEM25 have been associated with regulating colorectal cancer development and progression [18]; In breast cancer, TMEM25 stands as a favorable indicator for prognosis and prediction [19], where its decreased expression enhances the sensitivity of MCF-7/PR cells to paclitaxel treatment [20]. Here, TMEM25 is linked to colorectal cancer.