MAPK8 and Parkinson disease: PQ-induced oxidative stress was described before to cause neurodegeneration with parkinsonism-like symptoms, accompanied by strong immune activation and upregulation of JNK signaling in the CNS (Maitra et al., 2019), an activation profile similar to the identified activated plasmatocyte cluster C6 and the activated fat body clusters C2 and C4 in our snRNA-seq analysis.