Both α‐syn and DJ‐1 protein levels reduced in the presence of temozolomide in SK‐MEL‐28 melanoma spheroids suggesting that α‐syn and/or DJ‐1 may be implicated in common mechanisms underlying melanoma chemosensitivity, the toxic effect of temozolomide or signaling pathways that reverse chemo‐resistance.71 The gene discussed is PARK7; the disease is melanoma.