To address this, we conducted a three‐pronged analysis by: (i) identifying the association of α‐syn (SNCA) and DJ‐1(PARK7) through the α‐syn PPI networks, (ii) further investigating their interaction by identifying the protein‐binding domains via molecular docking studies, and (iii) examining their co‐occurrence in melanoma cells. The gene discussed is PARK7; the disease is melanoma.