Testis‐specific protease 50 (TSP50) is a recently discovered oncogene that has been observed to exhibit elevated expression levels in a range of cancer types, including gastric cancer, colon cancer, and various others.[7, 8, 9, 10] Furthermore, heightened expression of TSP50 has been associated with an unfavorable prognosis in gastric and colon cancers.[11, 12] However, the precise role and underlying mechanisms of TSP50 in intestinal diseases remain poorly understood. The gene discussed is PRSS50; the disease is cancer.