TSP50 exhibited substantial upregulation in diverse malignancies, including gastric, colorectal, and mammary neoplasms and it played pivotal roles in a wide array of biological processes, comprising tumor cell proliferation, apoptotic events, and metabolic activities.[7, 8, 9, 10, 24] Fascinatingly, our investigation revealed that heterozygous mice exhibited a greater propensity for developing exacerbated colitis compared to their pure heterozygous counterparts, as observed in both systemic and intestinal stem cell‐specific TSP50 knockout mouse models. Here, PRSS50 is linked to neoplasm.