PRSS50 and colitis: TSP50 exhibited substantial upregulation in diverse malignancies, including gastric, colorectal, and mammary neoplasms and it played pivotal roles in a wide array of biological processes, comprising tumor cell proliferation, apoptotic events, and metabolic activities.[7, 8, 9, 10, 24] Fascinatingly, our investigation revealed that heterozygous mice exhibited a greater propensity for developing exacerbated colitis compared to their pure heterozygous counterparts, as observed in both systemic and intestinal stem cell‐specific TSP50 knockout mouse models.