After tamoxifen‐induced knockout of TSP50 in Lgr5+ cells within the mouse intestinal tract, survival and body weight of mice were monitored and the result suggested that the absence of TSP50 in intestinal stem cells (Lgr5CreTSP50fl/+, Lgr5CreTSP50fl/fl) during DSS‐induced colitis resulted in profound weight loss and heightened mortality rates compared to the control TSP50fl/fl mice (Figure 2a,b). This evidence concerns the gene PRSS50 and colitis.