The extreme sepsis response endotype is characterized by higher frequencies of interleukin-1 receptor type 2-expressing (IL1R2+) immature neutrophils, epigenetic and transcriptomic signatures of emergency granulopoiesis in hematopoietic stem and progenitor cells, and signal transducer and activatior of transcription 3 (STAT3)-mediated gene expression signature (27). This evidence concerns the gene IL1R2 and Sepsis.