After searching the target genes with significant SNP regulatory effects which were integrated with cis-eQTL data in the eQTLGen database (see Supplementary Tables S4-S7), the molecular mechanisms of the IVs of four exposure factors (ieu-b-4843: HDL cholesterol; met-d-ApoB_by_ApoA1: ratio of apolipoprotein B to apolipoprotein A1; met-d-Total_C: total cholesterol; and ukb-d-30640_raw: apolipoprotein B) on thyroid cancer were explored by conducting a functional enrichment analysis and constructing a PPI network and a TF–gene network. This evidence concerns the gene APOB and thyroid gland carcinoma.