SREBF1 and liver cancer: The multikinase inhibitor sorafenib targets SCD1 through the ATP-AMPK-mTOR-SREBP1 pathway to suppress MUFA synthesis, disrupt lipogenesis, induce liver cancer cell death, and enhance sensitivity to sorafenib (89, 90) Docetaxel effectively impedes the tumor progress in PRAD by down-regulating mRNA and protein levels of SREBP1 and SCD1.