ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: Strengths of our study include (a) a reasonably large sample size that is representative of the Kuwaiti adolescent population and the use of several statistical approaches to robustly show the association between ANGPTL8 and obesity; (b) none of the participants was diagnosed with any form of diabetes and this allows our study to be focused only on obesity-related features; and (c) an ANGPTL-based prognostic model with reasonable accuracy is presented.