We also evaluated the levels of IL-10 in our cohort and observed a trend for reduction with increased obesity - mean (SD) values of IL-10 were 1.79 (1.92) pg/mL, 1.34 (1.7) pg/mL, and 1.45 (1.4) pg/mL in normal-weight, overweight and obese groups, respectively, albeit with no statistical significance (Figure 2D). This evidence concerns the gene IL10 and obesity due to melanocortin 4 receptor deficiency.