ANGPTL8 and obesity due to melanocortin 4 receptor deficiency: The main limitations of this study is (a) the lack of data on the lipid profiles of the participants which prevented us from evaluating the association between ANGPTL8 and lipoprotein levels in this population; (b) the lack of data on sex hormones which prevented us from examining the impact of sex hormone levels on the ANGPTL8 levels and obesity levels; and (c) the lack of a cohort of obese adolescents with insulin resistance which prevented us from examining levels of ANGPTL8 in the context of obese diabetes.