In IgA nephropathy, LYZL1 and SIPA1L3 risk genotypes are related to the decrease of Dialister and Bacilli and the risk genotypes of PLTP and AL365503.1 were associated with increased abundance of Erysipelotrichaceae and Lachnobacterium (13). The gene discussed is LYZL1; the disease is IgA glomerulonephritis.