Data mining of the published microbial quantitative trait loci indicated that the risk genotypes of rs2294239 (ZNRF3) and rs3747113 (SPECC1L) in diabetic nephropathy were correlated with the abundance of Lactococcus, which is a microorganism that is beneficial to the human body (18, 19) (Table 5). This evidence concerns the gene ZNRF3 and diabetic kidney disease.