ACSL4 and liver dysplastic nodule: Iron chelators are also effective in inhibiting ferroptosis and slowing the progression of DN by reducing excess intracellular iron, as the occurrence of ferroptosis depends on the generation of large amounts of ROS from excess intracellular iron via the Fenton reaction (35).The ACSL4 inhibitor rosiglitazone has been shown to markedly improve the survival of and renal function in DN mice and reduce renal MDA and iron levels (15).Huang et al.