This finding may be because of genetically inherited dysfunctional Beta-Cell genes (KCNJ11, KCNQ1, MTNR1B, IGF2BP2, rs7754840 and rs7756992 in CDKAL1) that cause insulin resistance and familial predisposition to insulin secretory defects passed on from one generation to another that cause hyperglycaemia. This evidence concerns the gene IGF2BP2 and Insulin resistance.