HMGCR and urinary bladder cancer: To the best of our knowledge, there has only been one MR study that employed merely one SNP named rs12916 as a surrogate for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, HMGCR), the target of statins, to investigate the association between statins use and the risk of bladder cancer (11).