In pathological conditions, like immune thrombocytopenia (ITP), autoantibodies against platelet GPIb and CD8+ cytotoxic T cells can induce Fc-independent platelet activation, sialidase neuraminidase-1 translocation, and platelet desialylation, leading to platelet clearance in the liver, which can be ameliorated by the sialidase inhibitor, oseltamivir [9,10]. This evidence concerns the gene CD8A and autoimmune thrombocytopenic purpura.