Since there is no statistical significance in expression values of MCOLN1 or TRPV4 in chemo resistance group as compared to chemo sensitive group, but the assembly of the presented three gene panel risk score is urging their relevance in contributing to disease malignancy, we speculate that those genes prominently insect in other colon cancer cell processes than those regulating drug resistance. This evidence concerns the gene TRPV4 and colonic neoplasm.