MCOLN1 and malignant colon neoplasm: According to the public data analysis results show that TRPV4 is highly expressed in colon cancer tissues while it is low expressed in normal tissues (p = 1.8e-12) (Fig. 6A), However, MCOLN1 and TRPM5 are both highly expressed in normal tissues, while low expressed in tumor group (p = 1e-07, p = 2e-05; respectively) (Figs. 6B and 6C).