Recently, Sushrut’s team identified for the first time a specific exosome that targets antisense oligonucleotides controlling the macrophage phenotype, leading to greatly enhanced potency of STAT6 expression, effectively inducing reprogramming of TAMs to the M1 phenotype and generating an efficient immune response that sustains TME in a pro-inflammatory and anti-tumor state [87]. The gene discussed is STAT6; the disease is neoplasm.