A study showed that exosomal miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p) from CRC patients significantly promote EMT and VEGF by activating PI3K/AKT signaling pathway, leading to PTEN-induced macrophage M2 polarization and colorectal cancer liver metastasis [73]. The gene discussed is AKT1; the disease is colorectal carcinoma.