Overexpression miR-155-5p in M2 macrophage-derived exosomes promotes CRC cell proliferation, antigenic capacity, enhanced CD3 T cell and IFN-γ T cell proliferation, and significantly reduces IL-6 expression levels, leading to colon cancer the immune escape and induction of tumor formation [25]. The gene discussed is IFNG; the disease is malignant colon neoplasm.