MAPK8 and cancer: It serves as a promising natural phytochemical in the prevention of cancer by following molecular mechanisms; (a) modulation of cancer signaling pathways like MAPK, PI3K/Akt, JNK, etc., (b) inducing apoptosis by stimulating NF-kB pathway and cell cycle arrest in G2 and G1 phase by modulating GSTP1 and Cyp1A1 polymorphism, (c) reducing MMP [50].