The prime mechanism of action of SAs is the activation of apoptotic cell death in a particular cancer cell line, which includes briofilin, which enhances the expression of Bax protein levels, suppresses levels of caspase-3 and Bcl-2 along with segmentation of poly (ADP-ribose) polymerase-1 (PARP-1) in HeLa cells. This evidence concerns the gene PARP1 and cancer.