THBS1 and neoplasm: CD47 interacts with several receptors and molecules, including TSP-1 and SIRPα, to activate downstream pathways such as Akt/mTOR, NF-κB, PI3K/Akt, RhoA/ROCK, and others, to regulate cellular processes such as tumor cell survival, invasion, angiogenesis, cell migration, and apoptosis.