GJB1 and X-linked Charcot-Marie-Tooth disease: As CMTX is caused by lack of expression of functional Cx32 (e.g., defective trafficking mutants) or alterations of the properties of the mutant Cx32, gene therapy where a copy of the WT gene can be expressed to compensate for the missing function is a potential treatment under active development (Sargiannidou et al., 2015; Schiza et al., 2015; Kagiava et al., 2016, 2018, 2021a,2021b).