CLIC1 and neoplasm: Similarly, the chloride intracellular channel-1 (CLIC1) is known to be instrumental for tumor proliferation in several solid tumor including GB and his overexpression on GSCs is inversely associated with patient survival (Setti et al., 2013), suggesting CLIC1 to be a potential target and prognostic biomarker (Randhawa and Jahani-Asl, 2023).