Time to CV death, time to first heart failure hospitalization, relative change in NT-proBNP.Time to the first occurrence of cardiovascular events.Time to sudden death or resuscitated sudden cardiac arrest.Number of visits to an ER due to HF (where intravenous therapy is required).Number of days alive out of the hospital.Number of ventricular fibrillation or sustained ventricular tachycardia. This evidence concerns the gene NPPB and heart failure.