The biomarkers of bone metabolism, namely, osteocalcin (BGP), parathyroid hormone (PTH), 25-OH VD, and type 1 procollagen amino terminal extender peptide (P1NP) are sensitive, specific, and non-invasive clinical aids to the diagnosis of osteoporosis, and can enable accurate evaluation of bone turnover at the level of intact bone tissue (Balsan et al., 1986). The gene discussed is PTH; the disease is osteoporosis.