When looking at the effect that the overexpression of PGRN-1 had, we notice that it was able to reduce paralysis levels across all disease models tested, suggesting PGRN is, in fact, an effective and broad protective factor against neurodegenerative diseases; however, at this stage we cannot rule out that the tagged PGRN-1 is acting as a modifier of the phenotypes we are studying. Here, GRN is linked to neurodegenerative disease.