While the multiplicity of changes associated with CAT may create a sense of great molecular complexity, or stochasticity, it should be noted that properties of the tumor microenvironment are, to some extent, defined by the consequences of the oncogenic transformation that triggers and propels cancer cell growth, invasion, and, importantly, also interactions with other cellular populations, as well as the composition of the cellular transcriptome, secretome and coagulome. Here, CAT is linked to cancer.