The expression of coagulation-associated genes on the other hand, followed the opposite trend where the astrocytic and mesenchymal clusters that showed lack of CDKN2B expression exhibited a significant concentration of cells with high procoagulant gene expression, including, but not limited to PDPN, which has been proposed as potential major contributor to CAT in GBM (Figure 2A) (6, 57). This evidence concerns the gene PDPN and glioblastoma.