Vitamin C significantly increases superoxide dismutase, catalase and glutathione and decreases serum TNFα and IL-1β levels in a rat ARDS model (9), while severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) downregulates the expression of type-1 interferons (the host’s primary anti-viral defence mechanism) (10), Vitamin C may also mitigate the increased risk of severe COVID-19 associated with upregulated ACE2, a receptor for the virus, and can prevent ACE2 upregulation induced by certain factors (11). The gene discussed is ACE2; the disease is COVID-19.