integrated genomic and transcriptomic data, divided CD30+DLBCL into three subtypes and screened out the corresponding three genes with the highest mutation frequency: TNFAIP3, SOCS1, and CIITA. Further validation analyses of the three genes on DLBCL cell lines revealed that the silencing of TNFAIP3, SOCS1, and CIITA genes could upregulate CD30 expression and make the DLBCL cell line sensitive to BV (74). This evidence concerns the gene TNFRSF8 and diffuse large B-cell lymphoma.