observed in adult T-cell leukemia/lymphoma (ATL) cells that CD30 and CD30L can form huge clusters on the membrane surface of cells expressing CD30 and CD30L and that CD30 triggers the internalization of the cluster complexes by extracting CD30L and part of its plasma membrane from neighboring cells, and these complexes simultaneously generate signal signalosomes that activate intracellular signaling and are ultimately degraded in lysosomes (43) (Figure 1). This evidence concerns the gene TNFSF8 and lymphoma.