In addition, with the further development of research, a large number of studies have found that CD30 can activate the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways by recruiting TRAF factors, thus playing an anti-apoptotic and pro-survival role in tumor cells (20–22). This evidence concerns the gene TNFRSF8 and neoplasm.