found that mast cells exist in HL, and 66% of CD30L+cells are mast cells (52), and later found that cross-linking of CD30 with CD30L induced the secretion of the chemokines IL-8, macrophage inflammatory protein-1α (MIP-1α), and MIP-1β from mast cells (53). This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.