showed that the median PFS time of BV combined with the CHP regimen for CD30+PTCL was significantly prolonged compared with the CHOP regimen, and the combination regimen had a consistent advantage in all subgroups (3), which has thus established BV combined with chemotherapy as the first-line treatment in CD30+PTCL. This evidence concerns the gene TNFRSF8 and mature T-cell and NK-cell non-Hodgkin lymphoma.