VEGFA and neoplasm: Tumor cells can damage vascular endothelium, activate platelets to release vascular endothelial growth factor to repair endothelial cells, promote the formation of tumor neovascularization and the adhesion of tumor cells to the vascular wall, resulting in tumor cell proliferation and metastasis, and thus forming a vicious cycle (29).Therefore, higher neutrophil and platelet counts and lower lymphocyte counts, i.e. high SII tend to suggest that patients are at higher risk of tumor recurrence and have a worse prognosis.