Our previous studies confirmed that SFRP4 expression was increased in CAD and originated mainly from epicardial adipose tissue (EAT), which is a special type of perivascular adipose tissue that can secrete anti-inflammatory factors, inhibit the differentiation of proinflammatory immune cells, and maintain the normal function of blood vessels (8, 22, 23). This evidence concerns the gene SFRP4 and coronary artery disorder.