SFRP2 also has a strong protective effect on hypoxia-induced myocardial cell injury in acute myocardial infarction by activating the Wn3a pathway and increasing the expression of MMP2 and MMP9, and its mechanism is highly similar to that of SFRP1 (7, 10, 11). Here, MMP9 is linked to acute myocardial infarction.