Unlike CB2R, activation of CB1R has been shown to exacerbate the severity of CER-AP (Dembinski et al., 2006), while inhibition reduced the severity of sodium taurocholate-induced AP (NaTC-AP) in rats (Matsuda et al., 2005), a severe biliary necrotizing model with a high mortality (Wan et al., 2012). This evidence concerns the gene CNR1 and alkaline phosphatase measurement.