FOS and alkaline phosphatase measurement: Intrathecal administration of CGRP antagonist (CGRP8-37) significantly decreased the number of Fos-like immunoreactive nuclei at levels T9, T11, and L1 in L-Arginine-induced AP (ARG-AP) in rats, a commonly used necrotizing model induced by disturbed amino acid metabolism (Wick et al., 2006b).