During the transition from acute to chronic pancreatitis, it was observed that the expression of TRPV1, TRPA1, and pERK in the pancreatic afferents was up-regulated; and this could be blocked by early (before week 3), but not late, intervention with TRPA1 and TRPV1 channel antagonists, leading to attenuated inflammation and pain-related behaviors (Schwartz et al., 2013). This evidence concerns the gene TRPV1 and chronic pancreatitis.