In neurological cancers, it has beenreported that NETs generate by tumor-infiltrating neutrophils (TINs) regulated the connection between glioma and tumor microenvironment in patients with malignant glioma via the mediation of HMGB1/RAGE/IL-8 axis (Zha et al., 2020). The gene discussed is CXCL8; the disease is neoplasm.