SHMT2 and neoplasm: The results showed that the expression of the SHMT2 gene was closely related to tumour proliferation, DNA repair, the G2M checkpoint, MYC-targeted genes and DNA replication (Figs. 4A–4E; P = 2.85e−32, CI [0.48–0.63]; P = 8.19e−39, CI [0.53–0.67]; P = 2.7e−39, CI [0.54–0.67]; P = 8.29e−45, CI [0.58–0.70]; P = 6.76e−32 CI [0.54–0.67]).