MAPT and Alzheimer disease: In addition, results from preclinical studies suggest that TREM 2-related microglia activation can have beneficial effects on tau hyperphosphorylation (Jiang et al., 2014; Leyns et al., 2019) and Aβ phagocytosis (Yeh et al., 2016; Parhizkar et al., 2019), and these studies demonstrate that TREM 2 may be of research value in AD treatment.