USP15 and neoplasm: Under the help of CRISPR/Cas9 gene editing technology, many properties and functions of tumor-suppressor genes have been characterized such as Kelch-like ECH-associated protein 1 (KEAP1), ubiquitin-specific peptidase 15 (USP15), LKB1, and members of SIK family (Table 1), which will provide a solid foundation for treatment of patients with identified aberrations in lung cancer.