In addition, silencing SMAD3/SMAD4 downstream of TGF-β leads to the downregulation of Myocardin (MYOCD) mRNA expression, subsequently impedes TGF-β-induced epithelial-mesenchymal transition (EMT) and metastasis in NSCLC, indicating the correlation between MYOCD and SMAD3/SMAD4 in TGF-β induced EMT (Tong et al., 2020). This evidence concerns the gene SMAD4 and non-small cell lung carcinoma.