NFKB1 and neoplasm: In these areas, tumor hypoxia and inflammation mechanisms are interconnected, being highly regulated by hypoxia-inducible factors (HIFs) and nuclear factor kappa B (NF-κB), which are responsible for activating genes associated with the promotion of tumor growth and progression and activation of cells within the TME (D’Ignazio et al., 2017; Belli et al., 2018; Petrova et al., 2018; Sormendi and Wielockx, 2018; Aguilar-Cazares et al., 2019; Roma-Rodrigues et al., 2019; Watts and Walmsley, 2019).