MAPT and early-onset autosomal dominant Alzheimer disease: Similarly, in a study by Apostolova et al., whose aim was the pathologic validation of the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol, they demonstrated significant associations between the hippocampal subfield volume and Braak staging (a method used to classify the severity of neurofibrillary tangle pathology), tau, Aβ burden, and neuronal count.