Aβ deposition is associated with neurodegeneration, inflammation, and neuronal cell death in AD.259β-secretase-1 (BACE1) cleaves amyloid precursor protein (APP) to generate the amyloid-β 1–42 and amyloid-β 1–40, one of the inciting events in AD pathophysiology. The gene discussed is BACE1; the disease is Alzheimer disease.