MIAT and atrial fibrillation: After ROC analysis was performed, it revealed that MIAT had the same diagnostic value as cTnT.214 Mechanistically, MIAT exhibits a pro-apoptotic effect in cardiomyocytes by sponging miR-22-3p and, in turn, upregulating the death-associated protein kinase 2 (DAPK2).215 Although MIAT is purported in many studies as a specific biomarker for AMI, in another study MIAT was found to be upregulated in the plasma and EVs of patients with atrial fibrillation (Afib).