In contrast, a serum EV-derived lncRNA growth arrest specific 5 (GAS5) was observed to be downregulated in NSCLC patients with respect to control patients with an AUC of 0.857 and when it was combined with Carcinoembryonic Antigen (CEA, a conventional tumor marker) the AUC went up to 0.929 making this a very promising biomarker.149 Another study has implicated low EV-GAS5 to mechanistically promote angiogenesis in the tumor supported by in vivo analysis.150. Here, CEACAM5 is linked to neoplasm.