BACE1 and Alzheimer disease: BACE1-AS was also elevated in the brain tissue of patients with AD and APP transgenic mice.260 Circulating BACE1-AS, which acts by sponging miR-214-3p, was elevated in a small cohort of 35 AD patients.261 In another study with 72 AD participants, circulating BACE1-AS levels in sEVs were significantly higher compared to 62 controls.