EV-derived H19 has been recently implicated in gefitinib resistance of NSCLC as well.153 An EV lncRNA HOXA Distal Transcript Antisense RNA (HOTTIP) (oncogenic) was found to be a prognostic marker that can predict the relapse (AUC = 0.935, for 1st post-operative sample) by serially checking for this lncRNA in the serum of NSCLC patients from pre-surgical to post-surgical state (between 3–6 months).154. Here, H19 is linked to non-small cell lung carcinoma.