This aspect was highlighted in a recent study wherein lncRNA Long Intergenic Non-Protein Coding RNA 659 (LINC00659) was significantly upregulated in EVs derived from CAF rather than normal fibroblasts (NF) from CRC patients.155 This lncRNA was observed to be transferred to CRC cells, where it acted as a sponge for miR-342-3p to increase ANXA2 expression and promote cancer progression. The gene discussed is LINC00659; the disease is colorectal carcinoma.