In AD patients, correlations with mini-mental state exam (MMSE) score, and proteins Aβ42, t-tau and p-tau showed that MALAT1 and FOXQ1, in plasma and CSF, correlated with decreased disease severity, while miR-125b, PTGS2 and CDK5 correlated with increased disease severity.264 On the other hand, serious specificity concerns arise when considering the influence of cancer265 and other prevalent conditions on MALAT1 levels. This evidence concerns the gene MALAT1 and Alzheimer disease.