Metastasis associated lung adenocarcinoma transcript 1 (MA LAT-1), a well-established lncRNA for its pivotal role as a promising prognostic marker in lung cancer,142 was also identified by Zhang et al. in 2017 to be expressed abundantly in serum EVs of NSCLC patients with an AUC of 0.703.143 In this study, serum EV-derived MALAT-1, analyzed using qPCR, was also positively associated with tumor stage and lymphatic metastasis. This evidence concerns the gene MALAT1 and lung cancer.