USP22 and colorectal carcinoma: EV-lncRNAs KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) secreted by CRC tumor cells acted as a ceRNA on the miR-30a-5p/USP22 axis by regulating PDL-1 ubiquitination thereby inhibiting CD8+ T cell s.171 This autocrine effect mediates immune escape by CRC tumor cells and aids in CRC progression.