After ROC analysis was performed, it revealed that MIAT had the same diagnostic value as cTnT.214 Mechanistically, MIAT exhibits a pro-apoptotic effect in cardiomyocytes by sponging miR-22-3p and, in turn, upregulating the death-associated protein kinase 2 (DAPK2).215 Although MIAT is purported in many studies as a specific biomarker for AMI, in another study MIAT was found to be upregulated in the plasma and EVs of patients with atrial fibrillation (Afib). Here, DAPK2 is linked to atrial fibrillation.