ACE and early-onset autosomal dominant Alzheimer disease: Exomeres show enrichment for heat shock protein 90 alpha family class B member 1(HSP90AB1) while supermeres are enriched in several proteins that are associated with diseases such as transforming growth factor beta-1 (TGFβ1-associated with colon cancer), amyloid precursor protein (APP-associated with Alzheimer’s disease), α-enolase and glypican-1 (associated with cancer), angiotensin-converting enzyme and angiotensin-converting enzyme 2 (ACE and ACE2 associated with cardiovascular disease and COVID-19).59,60