Certain studies have observed the release of α-synuclein in EVs in mouse models of PD273 and further, EVs derived from brain tissue of dementia seem to be able to contribute to the formation of Lewy bodies demonstrated by in vitro and in vivo models.274 To further probe the mechanism of such EVs, Zou et al. performed a microarray analysis in neuronal-derived EVs with L1 cell adhesion molecules (L1CAM) isolated from blood using antibody-based capture, that was also positive for α-synuclein. Here, L1CAM is linked to dementia.