The biomarker role of HOTAIR in BC was confirmed by Wang et al in another study where it was noted to be correlated with ErbB2/HER2 positivity (n = 23).181 Another serum EV-lncRNA plasmacytoma variant translocation 1 (PVT1) was found to be elevated in colon cancer patients and the cellular PVT1 through miR-152-3p/VEGFA axis promoted stemness and metastasis of cancer.182. The gene discussed is PVT1; the disease is cancer.