CEACAM5 and colorectal carcinoma: In 2016, Liu et al.examined the serum EV-derived CRNDE-h expression in CRC patients (n = 148) and found that its expression was significantly upregulated when compared to controls (n = 80).169 Its biomarker potential (AUC = 0.892) was better than the traditional CEA biomarker (AUC = 0.688), with their combination being even better (AUC = 0.913).