SACK1H and breast cancer: EV-derived lncRNA GS1-600G8.5 has been reported using in vitro and in vivo studies to be secreted by brain metastasis of BC cells, and it appears to compromise the integrity of the Blood-Brain Barrier further facilitating secondary tumors in the brain.177 Serum-derived FAM83H antisense RNA 1 (FAM83H-AS1) and lncRNA activated by TGF β (lncRNA ATB) were evaluated in 90 BC patients for their biomarker role.