Based on this, Long Intergenic- POU class 3 homeobox 3 (Linc-POU3F3), known for its role in the autophagic lysosomal pathway, was selected for further analysis.272 Upon comparing the levels of plasma-EV derived Linc-POU3F3 in 93 PD patients and 85 controls, this lncRNA was upregulated in PD patients, while α-synuclein was also elevated in these EVs. Here, SNCA is linked to Parkinson disease.