MAPT and Alzheimer disease: It was found that a dual-phase relationship exists in amyloid-positive individuals with increased connectivity with low neocortical tau and decreased connectivity with elevated flortaucipir levels, suggesting hyperconnectivity followed by hypoconnectivity phases during pre-clinical Alzheimer’s disease.201 Flortaucipir binding did not impact the association between default mode network and cortical thinning in participants with abnormal amyloid-PET.211