Biopsy led to the diagnosis of anaplastic astrocytoma, with molecular features of GBM: MGMT-unmethylated, IDH1 WT, EGFR A298V/amp, TERT promoter mutation, CDKN2A/B deleted prompting an integrated diagnosis of GBM, WHO Grade 4. This evidence concerns the gene CDKN2A and glioblastoma.