The patients who were using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs), beta blockers, spironolactone, gabapentin, and proton pump inhibitors (PPI) were at a higher risk of developing severe hyponatremia than those not taking these medications (p=0.03, 0.008, 0.01, 0.009, and 0.008, respectively). This evidence concerns the gene ACE and Hyponatremia.