APP and Alzheimer disease: Biological processes such as postsynapse organization, cognition, and locomotory behavior were enriched in genes (Mapt, Gabrb3, App, Ppp3cb, and Slc8a2) (Supplementary Table S4) with directional coherence for Plcg2*M28L human AD changes in Consensus Cluster C (Figure 4C, Supplementary Table S5).