SORL1 and Alzheimer disease: Next, we isolated the homologous genes exhibiting directional coherence between the effects of selected genetic risk variants (Abca7*A1527G, Mthfr*677C>T, Sorl1*A528T, and Plcg2*M28L) and changes in expression in human AMP-AD co-expression modules at 12 months and performed Gene Ontology (GO) enrichment analysis.