<h4>Introduction</h4>MODEL-AD is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to more accurately mimic LOAD than commonly used transgenic models.<h4>Methods</h4>We created the LOAD2 model by combining APOE4, Trem2*R47H, and humanized amyloid-beta. The gene discussed is TREM2; the disease is Alzheimer disease.